Sejung Lee Contact

Cancer evolution, tumor genomics, and structural variation

I use patient-derived genomic data to identify driver mutations, characterize structural variants, and reconstruct how tumors evolve.

Publications

  1. 2026

    Translating whole-genome doubling into precision medicine in cancer

    Lee, S.*, Lim, J.*, & Bhin, J. *Co-first authors

    Molecular Oncology (2026) · 10.1002/1878-0261.70302

    Review of how whole-genome doubling reshapes tumor genomes, and how that signal can be read as a clinically actionable feature in precision oncology.

  2. 2023

    Anti-inflammatory effects and macrophage activation induced by bioavailable cinnamon polyphenols in mice

    Song, Y., Jung, Y. S., Park, S., Park, H. S., Lee, S. J., Maeng, S., … & Kang, H.

    Molecular Nutrition & Food Research, 67(20), 2200768 · 10.1002/mnfr.202200768

    Bioavailable cinnamon polyphenols reduce inflammatory signalling and drive macrophage activation in a murine model.

Research experience

Graduate Research Assistant

M.S.–Ph.D. Integrated Program, Bhin Lab, Department of Biomedical Systems Informatics, Yonsei University

Mar. 2024 – Present Seoul, Korea

  • Breast cancer evolution — whole-genome sequencing National Research Foundation of Korea

    Reconstructed clonal architecture and the temporal ordering of major somatic events from WGS data, integrating SNVs, copy-number alterations, and structural variants to identify reproducible evolutionary patterns.

  • Ovarian cancer survival prediction — multi-omics National Research Foundation of Korea

    Built survival-prediction models on multi-omics datasets with robust time-to-event modeling, careful handling of censoring, and interpretable biomarker prioritization for clinical risk stratification.

  • Structural variant analysis — long-read sequencing National Research Foundation of Korea

    Characterized structural variants from long-read DNA sequencing using reproducible workflows for SV discovery, refinement, and functional annotation.

Undergraduate Researcher

B.S. in Genetic Engineering, College of Life Sciences, Kyung Hee University

Mar. 2018 – Feb. 2024 Seoul, Korea

  • Cinnamon bioactive ingredients National Research Foundation of Korea

    Studied memory improvement and anti-inflammatory mechanisms through inflammation, cytokine, and protein/gene expression assays. Co-authored the resulting publication (Song et al., 2023).

  • Functional beneficial bacteria NaturalendoTech

    Developed functional probiotic strains from traditional Korean foods, with cell-viability assays and protein/gene analysis.

  • Lymphedema prevention and therapy Korea Drug Development Fund

    Established a lymphedema mouse model and ran inflammation and cytokine assays.

  • Chemotherapy-induced leukocytopenia National Research Foundation of Korea

    Investigated biological response modifiers against chemotherapy-induced leukocytopenia and dysbiosis — murine condition control, FACS, Western blot, ELISA, and blood/organ harvest.

  • Cinnamon polysaccharide endotoxin tolerance National Research Foundation of Korea

    Studied endotoxin tolerance of polysaccharides and their effects on microbiota and intestinal immunity.

  • Wheat germ anti-inflammatory activity Ministry of Agriculture, Food and Rural Affairs

    Evaluated anti-inflammatory activity and immune elevation of wheat germ, handling murine condition control and cell-line maintenance.